Bacterial vaginosis (BV) is the most common cause of abnormal vaginal
discharge and has been associated with a range of serious health and
reproductive consequences.1A,2A Despite the availability of a number of oral
and intravaginal antibiotic treatment options, its management remains
challenging.1B More than 50 % of women experience recurrent episodes with
standard antibiotic-based treatments.1B,2A  A key factor is the failure of
antibiotics to fully eliminate vaginal biofilms adhered to cells lining the
vagina that contain abundant Gardnerella vaginalis 1C, also known as
bacterial vaginosis.

BV’s recurrent nature can have a substantial impact on women’s emotional,
sexual and social lives.3A  The most distressing symptom of BV is the
distinctive, strong, fishy odour that accompanies a thin, grey or white
vaginal discharge.3B,4A Women report feeling embarrassed, ‘dirty’ and
concerned that others may detect the malodour.3C

BETADINET BV Gel is a new, non-antibiotic treatment distributed by
Mundipharma South Africa, that has the potential to fulfil areas of unmet
clinical need in the treatment of BV.5A,6D  BETADINET BV Gel contains
astodrimer sodium, a novel dendrimer-based therapy with a physical mechanism
of action that disrupts vaginal biofilms and prevents harmful vaginal
bacteria from adhering to vaginal lining, reducing their opportunity to grow
whilst allowing normal vaginal flora to replenish.5A,6A,7A+B This helps to
normalise the vaginal pH while relieving odour and discharge.5A

BETADINET BV Gel has proven clinical efficacy and safety in 3 large
randomised trials in over 500 patients.6C,7C+D  BETADINET BV Gel provides
rapid relief from the unpleasant odour in just 24 hours.6B Because it acts
locally and is not absorbed systemically, BETADINET BV Gel avoids potential
issues associated with conventional antibiotics such as systemic side
effects, antibiotic resistance, and overgrowth of Candida is minimal.6A+E It
has a favourable safety profile and is well tolerated.6C  BETADINET BV Gel
is applied once-daily for 7 days.5B It is available over the counter (OTC)
from Clicks and other leading pharmacies.


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